Usually, infection does not occur with IV needle puncture when it is done strictly according to the requirements, but infection can occur when care is not taken properly. An IV needle is usually a medical device that is used in the clinic for infusion therapy, and such devices are sterile. When a patient needs to receive fluids for a long period of time, an IV needle puncture can be used to avoid repeated punctures. When an IV needle is threaded, a strict needle sealing operation is required, and usually, no infection occurs when it is used for a short period of time. If the patient’s vein is retained, the needle puncture time is too long, or during the puncture of the needle loosened, the patient infected with bacteria or viruses, etc., may cause venous retention, needle puncture secondary infection occurs. Patients should do a good job of local hygiene care after intravenous indwelling needle puncture, the needle hole at the loose should be timely, should be replaced in a timely manner. In the intravenous needle infusion treatment, the body appeared not adapt to inform the doctor or nurse in a timely manner, so as not to delay the condition caused by the danger.