Thigh muscles twitch and throb on their own Consider calcium deficiency, cold, muscle strain, Tourette’s syndrome, and lumbar disc herniation. 1. Calcium deficiency: Calcium deficiency can cause thigh muscle twitching and throbbing, which is common among the elderly, and if it happens frequently, it can be alleviated after calcium supplementation. 2. Catching cold: some people may get cold and cause thigh muscle spasm, local muscle twitching and throbbing, which can be alleviated by hot compresses or massages. 3. Muscle strain: strenuous exercise or walking too much can cause thigh muscle strain, thigh muscle excitability increases, twitching and throbbing, pain, rest after the symptoms are reduced. 4. Tourette’s syndrome: mostly occurring in children, involuntary, rapid, sudden muscle twitching occurs in many parts of the body, accompanied by psychological disorders. 5. Lumbar disc herniation: patients with lumbar disc herniation will experience twitching and throbbing in the innervated muscles due to the compression of the sciatic nerve. Thigh muscle twitching and throbbing need to go to the hospital if it happens frequently.