Uroepithelial tumors are common tumors of the urinary system and can occur in the renal pelvis, ureter, bladder, and male posterior urethra, with bladder tumors being the most common. “Uroepithelial tumors are located in the renal collecting ducts, calyces, and renal pelvis of the kidneys, as well as in the mucosal surface of the ureters, bladder, and urethra, and have the same covering epithelium, which is collectively known as uroepithelium. Cancer of these epithelia is called uroepithelioma. The incidence is almost three to four times higher in men than in women, and the incidence increases with age. Smoking and some occupational exposures are the most important predisposing factors for uroepithelial tumors. Uroepithelial tumors tend to be multifocal, a phenomenon known as “regional cancerization,” which occurs when the entire urinary tract epithelium is exposed to potentially carcinogenic substances excreted in the urine or activated by hydrolytic enzymes in the urine. Prompt medical attention is recommended when a diagnosis of uroepithelioma is made.