Older Cancer Patients Also Benefit From Radiotherapy

Tumors are age-related diseases, and the incidence of tumors in the elderly population increases significantly with age; more than 60% of tumor patients are 65 years old or older, and cancer has become the leading cause of death in people aged 60-79 years. Therefore, the focus of cancer control may be on how to effectively treat geriatric tumors and improve prognosis. Many clinicians and patients’ families are not yet aware of the problem of treating elderly cancer, and they believe that elderly cancer patients have poor tolerance, low benefit, and high toxicity to chemoradiotherapy, and this belief has led to many elderly cancer patients not receiving aggressive and effective treatment. Drug selection for elderly cancer patients is based on the same principles as those for middle-aged patients with advanced disease. For elderly patients with advanced cancer, treatment principles are first and foremost based on ensuring the patient’s quality of survival. A number of studies have confirmed the benefits of radiotherapy for elderly cancer patients: 1) The CALGB (Cancer and Leukemia Group B) analysis concluded that for breast cancer treatment, the elderly group had similar chemotherapy benefit rates as the younger group, with acceptable chemotherapy toxicity and no significant association between age and efficacy. A study published online August 9, 2011 in The Lancet showed that platinum-containing two-drug chemotherapy significantly reduced mortality in older patients with non-small cell lung cancer (NSCLC) by 36%. 3) Trumper et al. showed treatment of patients with esophageal cancer with similar efficacy and tolerability in the older and younger groups. 4) Sargent, Hoff et al. showed no significant difference in the efficacy and tolerability of chemotherapy for colon cancer between the elderly and the young. Studies have shown that elderly patients are able to tolerate and complete full doses of chemotherapy. Therefore, elderly cancer patients and their families should eliminate their fear of treatment and actively cooperate with treatment. If certain treatments can improve the patient’s quality of life or enhance survival, advanced age should not hinder the application of these treatments, and elderly people can tolerate the commonly used chemotherapy regimens as well as young people. The traditional view is that elderly people have poor physical function and are unwilling to undergo radiotherapy, so many elderly patients choose conservative treatment or even give up treatment. This is actually a misconception. Elderly patients should not give up lightly and miss the good opportunity of treatment. Studies have shown that age is not the main factor affecting the prognosis of cancer patients, and the effect of elderly patients is no worse than that of young patients after proper comprehensive treatment.