Cold, fever, cough and body ache may be associated with inflammatory mediators causing upper airway neural hypersensitivity and thermoregulatory point abnormalities. Colds are generally caused by viral infections, viruses in the invasion of the body to produce local inflammation at the same time will release a number of inflammatory mediators, common such as bradykinin, leukotrienes and tumor necrosis factor, resulting in patients with upper airway nerve hypersensitivity, coughing symptoms, affecting the body’s thermoregulatory center, causing fever. In addition to generalized soreness in addition to inflammatory mediators related to stimulation, but also may be a cold fever when the body produces too much lactic acid accumulation. When a cold, fever, cough and body aches occur, you can take acetaminophen and other medications to control the symptoms, the use of medication should be under the guidance of a doctor. If symptoms persist, it is recommended that you seek medical attention, complete a thorough examination, and follow your doctor’s instructions.