The decrease of lactobacillus in female vagina is considered to be related to vaginitis, endocrine disorders and other factors. 1. Vaginitis: Lactobacillus vaginalis is the normal flora of the vagina, through the decomposition of local glycogen to maintain the local acidic environment of the vagina, thus preventing the occurrence of vaginitis, if the patient has a combination of vaginitis, this time, such as Escherichia coli and other vaginal pathogens reproduce in large quantities, which inhibit the growth of Lactobacillus and lead to a reduction in its number. 2. Endocrine disorders: for women with reduced ovarian function, the level of estrogen in the body decreases significantly, which leads to a decrease in the number of vaginal lactobacilli and a decrease in local resistance, thus easily leading to the occurrence of senile vaginitis. For patients with a reduced number of lactobacilli in the vagina, it is recommended to go to the gynecology department of a regular hospital for consultation and active treatment under the guidance of a doctor after the cause of the disease has been clarified.