Under normal circumstances, the thickness of gallbladder wall is about 2mm, at present, the thickness of gallbladder wall is 9mm, which is higher than the normal value; in clinic, it is mostly seen in gallbladder stones, cholecystitis, adenomyosis of gallbladder, gallbladder cancer, etc. Whether it is serious or not is mainly decided according to the patient’s condition, benign diseases are not serious, but if it is cancer of the gallbladder, it is more serious. 1. Gallbladder stones and cholecystitis: In patients with gallbladder stones and cholecystitis, the wall layer of the gallbladder will be congested and edematous, and thickening of the gallbladder wall can be detected by ultrasound and other imaging examinations. Cholecystectomy and other surgical treatments are needed, and the recovery after surgery is good and not serious. 2. Adenomyosis of gallbladder: it is a benign disease of gallbladder, which is mainly due to hyperplasia of gallbladder glands and muscular layer, so the examination can find the thickening of gallbladder wall, and it is usually recommended to have surgery to remove the hyperplasia part of the gallbladder, and the healing is good and not serious after surgery. 3. Gallbladder cancer: it is a malignant tumor of gallbladder, which can cause thickening of gallbladder wall. Some patients can be cured after radical surgery and relevant auxiliary treatment in early stage, but if it is in middle or late stage, it is not easy to be cured and the consequence is serious. It is recommended to go to the hospital, complete all auxiliary examinations to clarify the condition and give relevant treatment by professional doctors.