Thyroid nodule grade 5 is highly suggestive of malignant nodules, with a malignancy rate of >90%. If it is a malignant nodule, without active treatment, it may cause tumor metastasis and so on. It is recommended to consult a doctor in time. Thyroid nodule grade 5 malignant degree is relatively high, when the tumor is close to the trachea, the laryngeal reentry nerve, it can violate the trachea, the laryngeal reentry nerve, with the continuous growth of the tumor, it may compress the trachea and cause respiratory difficulties. In addition, the thyroid gland is closer to the esophagus, when there is a tumor, it may grow to the back of the esophagus and invade the esophagus, and there is a tumor in the esophagus, which may affect the patient’s eating. The neck is rich in blood vessels, if the thyroid tumor grows toward the blood vessels it is easy to invade the blood vessels and arteries, and may form a venous thrombus or tumor thrombus. Meanwhile, the tumor itself contains abundant blood vessels, which may easily cause hemorrhage if there is a blood vessel rupture. For thyroid nodule rating of grade 5, follow the doctor’s instructions for further examination and targeted treatment or therapy with the doctor’s help.