If you eat too much seafood, you may get gout. Seafood belongs to high purine food, excessive eating may cause purine metabolism disorder, which leads to hyperuricemia, some patients can further develop into gout. Disordered purine metabolism is one of the key causes of gout, so excessive consumption of seafood will have a certain chance of getting gout.
Gout is a heterogeneous group of diseases caused by purine metabolism disorders and (or) uric acid excretion disorders, which are clinically characterized by elevated serum uric acid, recurrent acute arthritis, gouty stones and joint deformities, uric acid renal calculi, glomerular, tubular, interstitial, and vascular renal lesions.
Long-term high-purine diet, such as seafood, broth, animal offal and heavy alcohol consumption, can cause blood uric acid to rise rapidly in a short period of time, leading to acute attacks of gouty arthritis. Ethanol metabolism increases plasma lactate concentration, which inhibits renal tubular secretion of uric acid and reduces uric acid excretion, while ethanol also promotes the conversion of adenine nucleoside, leading to increased uric acid synthesis.
Elevated uric acid exceeds the metabolic load, it is easy to appear hyperuricemia, and will eventually form gout. Therefore, eating too much seafood will have a certain chance of getting gout.
Gout can also be caused by kidney disease, drugs, tumor chemotherapy or radiotherapy and other reasons, so gout patients need to consult a doctor in a timely manner, in accordance with the doctor’s instructions to improve the relevant examination to clarify the cause of the disease, and if necessary, drug treatment.