High estrogen may cause changes in multiple female organs, including the uterus, vagina, skin, and cardiovascular system. 1. Uterine manifestations: the uterine myocytes appear to be hyperplastic and enlarged, and the glands and interstitium of the endometrium are hyperplastic. The cervical opening is dilated compared to the normal state, and there is increased secretion of cervical mucus, which is thin and elastic in shape and easily stretched; 2. Vaginal manifestations: it can cause hyperplasia and keratinization of vaginal epithelial cells, thus manifesting as thickening of the vaginal mucosa; in addition, the labia develop plump and the pigment deepens; 3. Development of secondary sexual characteristics: it manifests as hyperplasia of breast ducts, coloring and deepening of nipples and areolas; 4. Skin manifestations : Water and sodium retention in the skin, excess estrogen will cause edema in the skin, which will also manifest in weight gain; 5. Cardiovascular performance: Estrogen is beneficial to the walls of women’s arteries, which can promote vasodilation and facilitate blood circulation and the exchange of oxygen and metabolites, making women look better. In addition, high estrogen in women may also occur in the uterus, vagina and other parts of the body, as well as menstrual disorders, etc. It is recommended that women balance the hormone levels in their bodies while actively treating diseases.