Patients with cramping and foaming and rolling eyes are having epileptic seizures, which may be epilepsy and require prompt medical attention for further examination. Epilepsy is a chronic brain disease with clinical manifestations of recurrent epileptic seizures, which can be manifested as motor, consciousness, mental, behavioral, and autonomic dysfunction, such as fuzzy consciousness, cramping, foaming, and pallor. Epilepsy is not an independent disease, but a group of diseases or syndromes. When the patient has symptoms of cramping, foaming and rolling eyes, further examination is needed to clarify the cause of the disease. If it is caused by cerebrovascular disease, it is called secondary epilepsy; if no relevant cause is found, it is called cryptogenic epilepsy. Family members should pay attention to the protection of the patient during seizures, and should not forcefully press the patient’s limbs to avoid fractures and dislocations; the patient’s head can be turned to the side to allow secretions to flow out to prevent suffocation.