Blackheads, also known as blackhead pimples or open pimples, can be removed by using retinoids, azelaic acid and benzoyl peroxide. 1. Vitamin A drugs: commonly used drugs are isotretinoin gel, adapalene gel, tazarotene gel, etc. These drugs can improve the keratinization of follicular sebaceous gland ducts, dissolve acne, so as to achieve the purpose of removing blackheads. 2. Azelaic acid cream: Azelaic acid has antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis, so as to achieve the purpose of treating blackheads, and is forbidden for those who are allergic to this product. 3. Benzoyl peroxide gel: this product is an oxidizing agent, after applying on the skin, it will release new ecological oxygen, which can kill Propionibacterium acnes and control the condition. In case of secondary infection, antibiotic preparations such as erythromycin ointment should also be used. All the above drugs should be used under the guidance of specialists to avoid blind use of medication, which may cause discomfort.