The hepatitis B virus infection requires antiviral therapy when the following conditions occur: 1. liver inflammation appears active, liver function is repeatedly abnormal, after liver preservation and enzyme lowering treatment still can not be normal, and the hepatitis B virus is high replication status, this time should be antiviral therapy. 2. although liver function is normal, liver ultrasound or liver fibrosis scan indicates the manifestation of fibrosis, this time also 3.Liver biopsy, which indicates a high degree of inflammation or fibrosis, should also be considered for antiviral treatment. 4.Liver ultrasound indicates cirrhosis of the liver, which should be treated with antiviral therapy for life.