Chest pain after drinking alcohol can be caused by coronary heart disease, esophageal heartburn and gastroesophageal reflux, etc., and should be diagnosed by a doctor in time. 1. Coronary heart disease: After drinking alcohol, patients with coronary heart disease may experience chest pain due to increased basal metabolic rate and increased heart rate, which may lead to increased symptoms of myocardial ischemia. 2. Esophageal burns: high concentration of alcohol can damage the mucosa of the esophagus, further causing pain and discomfort in the corresponding areas. 3. Gastroesophageal reflux: Drinking a large amount of alcohol will cause the stomach contents to reflux into the esophagus, and after the stomach acid burns the esophageal wall, it will cause the symptoms of post-sternal pain and discomfort. If you have chest pain after drinking alcohol and can’t relieve it, accompanied by activity limitation, you need to consult a doctor in time for observation and standardized treatment under the guidance of a clinician.