The thickening of the penile cuticle is considered to be related to repeated friction, or to factors such as excessively long foreskin and inflammatory infections of the reproductive system, as follows. 1. Repeated friction: for example, wearing fabrics that are particularly hard and repeatedly rubbing the genitals will easily lead to skin roughness and over-keratinization, thus resulting in thickening of the cuticle. 2. Circumcision: if there is a circumcision is not timely treatment, the formation of circumcision scale, do not pay attention to hygiene, secretions repeatedly stimulate the foreskin, glans tissue, may cause thickening of the stratum corneum. 3. Inflammation of the reproductive system: for example, prostatitis, scrotitis, orchitis, etc., stimulated by inflammation will form inflammatory secretions, if not cleaned up in a timely manner, easy to lead to the accumulation of keratin, and ultimately the formation of the stratum corneum. If the thickening of the penile cuticle is accompanied by discomfort, there may be other reasons, such as affecting the quality of sex life, it is recommended to consult a doctor in time and under the guidance of a professional physician treatment.