The skull is hard and resilient, and it acts as a protective shell for the brain, effectively defending it against external aggressions, but danger can occur at any time, and sudden traffic accidents, falling objects, and craniosurgery, among others, can easily result in injury to the skull. Once a piece of the skull is missing, the intracranial tissues will lack the necessary protection, and the impact is very significant. Therefore, when skull defect occurs, it must be taken seriously, and if the defect area is large, it is necessary to go to the hospital early for skull repair surgery, so that the integrity and closure of the cranial cavity can be restored and the intracranial tissues can function normally. Moreover, in neurosurgery, skull repair surgery is not a big surgery and the safety is very high, the key is to choose good materials and experienced physicians to perform the surgery. Currently most local hospitals are using titanium mesh material to carry out surgery, titanium mesh material than the previous materials are also a lot of progress, but still have some shortcomings, compared to the new polyether ether ketone peek material is more ideal. The peek material is a very advanced polymer material, its various properties are excellent, according to the patient’s head CT data for three-dimensional shaping, the post-operative effect is very natural and beautiful. Cranial bone repair peek material domestic and imported which is better? In fact, domestic and imported peek materials are basically similar, in fact, the raw materials are imported, but some are shaped in the domestic processing molding; if then to foreign processing molding, and then shipped back, then the cycle will be too long, in addition to foreign words epidemic risk is also relatively high. There is no problem to use domestic processing and shaping. At present, our team is using peek material to carry out skull repair surgery, and we also introduced the concept of aesthetic plastic surgery, comprehensive carry out peek skull repair plastic surgery, the postoperative effect is really good, highly praised by patients and families.