Sleeplessness may be caused by long-term non-excretion of semen, lack of sleep and other physiological factors, generally no need to take medication. However, if it is caused by prostatitis, urethritis and other diseases, you need to target oral penicillin drugs, quinolones. 1. Physiological factors: if the long-term non-existent, lack of sleep, lack of correct sexual knowledge, past history of masturbation, may lead to the cerebral cortex in a state of sexual excitement, so that the situation of sleeplessness. This kind of situation usually do not need to take drugs. 2. Prostatitis: Prostatitis symptoms are frequent urination, urinary urgency, urinary effort, incomplete urination, perineum, scrotum, groin area pain and discomfort, sometimes combined with erectile dysfunction, premature ejaculation, etc., may also stimulate the cause of sleeplessness. Patients can take oral oral a-blocker combined with sensitive antibiotic treatment under the guidance of the doctor, such as doxazosin, levofloxacin, doxycycline and so on. Specifically take which antibiotics need to carry out bacterial culture drug sensitivity test to determine. 3. Urethritis: patients with urethritis will have abnormal secretions, frequent urination, urination and other symptoms, and some patients will experience dreaming. Patients can take oral penicillin drugs, such as ceftriaxone sodium, macrolide, etc., or oral quinolones, such as norfloxacin, ofloxacin and other drugs under the guidance of the doctor. To summarize, if the patient has a long-term situation of wet dream, it is necessary to consult the doctor in time, to carry out relevant examinations, and to clarify the cause of the disease.