Mesenteric lymph nodes are located in the periumbilical region and mainly include superior mesenteric lymph nodes and inferior mesenteric lymph nodes. Superior mesenteric lymph nodes are around the beginning of the celiac trunk and collect lymphatic fluids from the stomach, liver, spleen and other organs; inferior mesenteric lymph nodes are located at the root of the homonymous artery and receive the output ducts of the lymph nodes from the left colon, the sigmoid colon and the rectum and collect lymph from these areas. The mesenteric lymph nodes are susceptible to inflammation, especially in winter and spring, often secondary to upper respiratory tract infections or intestinal inflammation. Patients presenting with mesenteric lymphadenitis have fever, abdominal pain, nausea, vomiting, and diarrhea, and lesions involving a group of lymph nodes at the end of the ileum can lead to periumbilical pain, accompanied by an elevation of white blood cells. If inflammation of mesenteric lymph nodes occurs, ultrasound examination is needed according to the doctor’s advice to determine the cause of the disease. In daily life, it is necessary to pay attention to a light diet and avoid spicy food.