There is no quick way to stop coughing in the middle of the night. General treatment, cause-specific treatment and symptomatic treatment are needed. General treatment is mainly to adjust the body position, it is recommended to take the side of the pillow to lie down. For the cause of the treatment: if it is caused by allergies, usually take anti-allergy drugs such as loratadine tablets, cetirizine hydrochloride tablets, etc.; bacterial infections caused by coughing, the general application of azithromycin, amoxicillin, etc.; lung tumors and cardiovascular disease caused by coughing, you should actively treat the original disease. At the same time, it should also be combined with symptomatic treatment. Coughing in the middle of the night can generally be applied to cough suppressants such as dextromethorphan, phenylpropylpiperine, etc., and phlegm removing drugs such as aminobromine hydrochloride dispersible tablets, acetylcysteine tablets and so on. If the symptoms fail to improve or even gradually worsen, it is necessary to consult a regular hospital in a timely manner, and cooperate with the doctor to improve the examination and standardized treatment.