Acid reflux in the stomach in the middle of the night after drinking alcohol may be caused by alcohol stimulation, gastroesophageal reflux and other reasons. It is recommended to improve the symptoms through food and medication. 1. Alcohol stimulation: After drinking alcohol, alcohol stimulates the gastric mucosa leading to an increase in gastric acid secretion, resulting in acid reflux symptoms. It is recommended to drink more water, drink some yogurt, which can promote the discharge of alcohol, reduce the content of alcohol in the body, but also can play a role in protecting the gastric mucosa, which is conducive to alleviate the symptoms of acid reflux. 2. Gastroesophageal reflux: Drinking alcohol may lead to spasmodic contraction of the smooth muscle of the gastrointestinal tract or gastrointestinal tract dysfunction, which in turn manifests itself in the phenomenon of esophageal reflux, and the patient will also experience acid reflux, heartburn and other symptoms. It is recommended to use magnesium aluminum carbonate, omeprazole, rabeprazole, etc. under the guidance of the doctor, which can help reduce the symptoms of acid reflux. After the above treatment, if the effect is not obvious, it is recommended to go to the hospital in time, after the doctor’s interview, combined with the relevant items of examination, to clarify the specific causes of the disease, and then follow the doctor’s instructions to the corresponding treatment.