The main sequelae of chordoma surgery are cerebrospinal fluid leakage, brain nerve damage, brainstem injury, meningitis, and other brain dysfunction. Patients with post-surgical sequelae require early and aggressive management. The prognosis for chordoma is not too good, with an average life expectancy of between six months and two years without any treatment. If aggressive surgery combined with radiotherapy is performed early, the patient’s life expectancy can be extended and survival rates improved. However, current studies have demonstrated that for patients treated with surgery combined with radiotherapy, the recurrence rate may be as high as 100% if surgical resection is incomplete. If the surgical resection is complete, the recurrence rate can be reduced, but the best treatment for chordoma is currently based on a combination of surgery plus radiation therapy.