Cough with blood and sputum at night should be treated according to the cause, common causes include tuberculosis, bronchitis, lung cancer, etc.. 1. Tuberculosis: Tuberculosis causes cough with blood and sputum at night, need to use anti-tuberculosis drugs for treatment, commonly used drugs are isoniazid, rifampicin; conservative treatment is ineffective can be surgical treatment. 2. Bronchitis: Cough with blood and sputum at night caused by bronchitis needs to be treated with anti-infective drugs, commonly used drugs include Roxithromycin, Amoxicillin, etc.; dextromethorphan, Pentoxyverine and other cough suppressants are used as appropriate; when sputum is not easy to be coughed up, sputum dissolving agents can be used such as aminobromine hydrochloride, bromohexine and so on. 3. Lung cancer: Cough with blood and phlegm at night caused by lung cancer can be treated with comprehensive treatment mainly by surgery. There may be other reasons for coughing up blood and sputum at night, so it is recommended to consult a doctor in time for examination, and then carry out targeted treatment after clarifying the cause of the disease in order to improve the condition effectively.