Coagulation abnormalities are mainly seen in hemophilia and vascular hemophilia. 1. Hemophilia: it is a kind of bleeding disorder with hereditary thromboplastin generation disorder, including hemophilia A and hemophilia B. Clinically, hemorrhage is often manifested, and the treatment is mainly based on replacement therapy, i.e., replenishing the missing coagulation factors, and the main agents include fresh frozen plasma, etc., as well as the general treatment for the treatment of hemostasis such as replenishing platelets, and there is no radical cure yet. 2.Vascular hemophilia: autosomal hereditary bleeding disorders, bleeding is the prominent feature, the treatment is mainly for the treatment of bleeding, according to the type of vascular hemophilia and bleeding episodes should be selected from the appropriate treatment plan. 1, 2 can be used to desmopressin, but there are cardiovascular and cerebrovascular diseases of the elderly patients with caution; alternative therapies can be used for any one type. There is no cure for congenital coagulation disorders, and prevention is the mainstay, but acquired coagulation disorders such as those caused by vitamin K deficiency can be treated and cured. People with coagulation disorders should be actively involved in treatment to prevent serious complications.