Feel itchy but do not know where itchy consider pruritus skin may be greater, mainly due to the following reasons: 1, the elderly sebaceous gland function is reduced, sebum secretion is reduced, the barrier function of the skin is weakened, in the skin surface can form a small break, resulting in the occurrence of pruritus skin. 2, due to excessive force rubbing the skin caused by the reduction of sebum, and the skin barrier function caused by the reduction. 3, 3, Due to the factors of medical disease, may be due to kidney failure or heart failure or serious coronary heart disease, diabetes, etc. triggered by the generation of pruritus. Then the clinical treatment can be oral levocetirizine hydrochloride capsules, combined with loratadine berries capsules, and topical application of glyburide lotion to carry out treatment.