Grade 2 hypertension alone is intermediate risk, but once combined with other cardiovascular risk factors and target organ damage, it can go to high risk or even very high risk, and can be controlled by lifestyle improvement and medication. Grade 2 hypertension is also called moderate hypertension, i.e. systolic blood pressure 160 ~ 179mmHg and/or diastolic blood pressure 100 ~ 109mmHg. At this stage, not only lifestyle improvement but also antihypertensive drugs should be taken for treatment. The use of antihypertensive drugs should follow several principles, i.e., starting with small doses, giving preference to long-acting agents, combination of drugs and individualization. There are five classes of antihypertensive drugs: diuretics, beta-blockers, calcium antagonists, angiotensin-converting enzyme inhibitors (ACEI), and angiotensin II receptor antagonists (ARB). The choice of drugs varies according to the patient’s age, history of underlying disease, and so on. Hypertensive patients are advised to visit the hospital in time to choose appropriate antihypertensive drugs and prevent complications.