Plasma lipoprotein is an indicator of blood lipids, mainly synthesized in the liver, with a normal range of 0-300 mg/L. Increased plasma lipoprotein is mainly seen in atherosclerosis, cerebral infarction, cerebral atherosclerosis, and acute chronological reaction, which is mainly seen clinically in acute myocardial infarction, surgery, and acute rheumatoid arthritis. Plasma lipoproteins are now recognized as an independent risk factor for atherosclerosis. It has also been well established that if plasma cholesterol concentrations are normal and plasma lipoprotein values appear significantly elevated, patients have a more than twofold increased risk of developing cardiovascular disease compared to the normal population. If both LDL and plasma lipoproteins are elevated, the risk of cardiovascular disease is more than eight times higher than in the normal population. Therefore, people with significantly elevated plasma lipoproteins should also be given high priority, especially those with elevated cholesterol, triglycerides or LDL, and should be treated with medication in a timely manner to reduce the risk of cardiovascular and cerebrovascular disease.