A positive closed-eye-difficulty sign is partially indicative of deep sensory deficits and is generally seen in subacute combined degeneration of the spinal cord. This test is a major screening tool for ataxia. During the examination, attention must be paid to protect the patient from falling, influence the patient to stand with both feet together and both arms stretched forward flat, and instruct the patient to open and close his eyes, if the patient’s body wobbles and fills with blood before and after closing his eyes, but stands smoothly when his eyes are open, the clinic is generally known as a positive sign of difficult to stand with eyes closed. If the patient’s body shakes or fills with blood when the eyes are open or closed, and the symptoms are more serious when the eyes are closed, it is usually seen in cerebellar lesions. Cerebellar lesions are characterized by dizziness, nausea, vomiting, balance disorders, and ataxia. At the same time, the patient may also have explosive speech, and cranial CT examination can make a clear diagnosis.