Thyroid nodule with lymphatic enlargement may suggest thyroid cancer, or it may be benign nodule with lymphatic reactive enlargement, it is recommended to improve the relevant examination to confirm the diagnosis. Thyroid nodule with lymphatic enlargement should be excluded from the presence of thyroid cancer, and ultrasound, pathologic biopsy and other tests should be performed to assess the benign or malignant nature of the nodule. Thyroid cancer can metastasize through lymph nodes, and thyroid cancer with enlarged lymph nodes may be a manifestation of lymph node metastasis in the neck, such as the central region. Benign thyroid nodules, such as thyroid adenoma, thyroid cyst, etc., lymph node enlargement may be a reactive enlargement of lymph nodes caused by infection and other factors. Thyroid gland with lymph node enlargement can be caused by a variety of reasons, and it is recommended that patients consult a specialist to comprehensively determine the cause of the disease based on clinical symptoms, other clinical examinations and other factors, and actively treat the disease.