With the increase in the number of patients with atrial fibrillation, many patients have become interested in radiofrequency ablation, which can cure atrial fibrillation, so many patients with atrial fibrillation have started to ask, if they have radiofrequency ablation, do they still need to take medication? In fact, despite the radiofrequency ablation, there are still some medications that need to be taken after the surgery, what are the specific medications? This article will elaborate on the commonly used drugs after surgery. I. Postoperative antiarrhythmic drugs Although the current technology of radiofrequency ablation is relatively mature, but according to the length of history of atrial fibrillation patients, the size of the left atrium, the operator’s technology and other related factors, atrial fibrillation patients in the intraoperative conversion to sinus rhythm, but the electrical instability, so some postoperative atrial fibrillation still has the possibility of recurrence, so in order to prevent the recurrence of atrial fibrillation and maintain sinus rhythm, for atrial fibrillation postoperative routine application of antiarrhythmic drugs. Commonly used drugs include Kotarolone, cardioplegia, betalactone, etc., which are taken for about 3 months according to the condition. Thereafter, the doctor will decide whether to continue the antiarrhythmic drugs according to the patient’s response after atrial fibrillation ablation. At present, the commonly used drugs in clinical practice are the first-line antiarrhythmic drugs of choice mainly class III classical antiarrhythmic drug amiodarone, which has a high success rate in maintaining sinus rhythm and is most widely used in clinical practice. However, because of more adverse effects of this drug, the application of this class of drugs should be more cautious. For most patients with atrial fibrillation who have undergone radiofrequency ablation, the contractile function of the atria cannot be fully restored within a short period of time after the conversion to sinus rhythm, and there is still a possibility of embolism, so generally clinicians will recommend patients to take anticoagulant drugs for 3 months, such as patients who choose warfarin need regular blood sampling to monitor coagulation function (INR control between 2-3). If newer anticoagulants such as rivaroxaban or oral anticoagulants such as dabigatranate are chosen, regular monitoring of INR indicators is not required. While taking anticoagulants, patients must pay attention to the presence of bleeding conditions in the body, such as bleeding gums, petechiae under the skin, black stools and other bleeding conditions. If bleeding is found, the anticoagulant needs to be stopped immediately and come to the hospital for review immediately. For patients who have been taking oral anticoagulant drugs for 3 months without recurrence of atrial fibrillation, whether to continue the application of anticoagulant drugs in the later stage needs to be further decided according to the thrombotic risk score CHADS2 or CHA2DS2-VASC score. Third, postoperative acid-suppressing and stomach-protecting drugs Many patients after RF ablation of atrial fibrillation will take oral acid-suppressing and stomach-protecting drugs, such as pantoprazole. Many patients do not understand why they need gastric protection when they undergo minimally invasive cardiac surgery. In fact, this is related to the site of RF ablation of atrial fibrillation. RF ablation of atrial fibrillation requires multi-site ablation of the inner wall of the left atrium, including pulmonary vein isolation,, and the esophagus is just behind the left atrium in relation to its adjacency. There is a possibility of thermal damage to it during RF ablation. To protect the esophagus, therefore, after RF ablation, 4-6 weeks of gastric mucosal protective agents (such as pantoprazole, rabeprazole and other proton pump inhibitors) are usually required. Patients are also advised to eat a light diet that is not too greasy. Avoid hard food and drinks that are too hot in the mouth. For patients with atrial fibrillation, most of them have hypertension, diabetes mellitus and other diseases. Although radiofrequency ablation cures atrial fibrillation, it is still necessary to actively control other comorbidities and actively apply medication.