The causes of right leg discomfort may be caused by neurological factors, hip joint diseases, knee joint diseases, vascular lesions and so on. 1. Neurological factors: sciatic nerve pain, mostly manifested as radiating pain and numbness from the posterior lateral thigh to the lateral calf and lateral foot, mostly seen in lumbar disc herniation, pyriformis syndrome, neuroinflammation, diabetes mellitus combined with peripheral neuropathy. 2. Hip diseases: such as femoral head necrosis, hip joint inflammation, hip bursitis, mostly manifested as hip pain and unfavorable activities, groin pain and pressure pain, and some of them will radiate to the anterior and medial thigh. 3. Knee diseases: most of them are seen in knee osteoarthritis, meniscus injury and other diseases, which will be manifested as knee pain, unfavorable flexion and extension activities, and aggravated pain when going up and down stairs. 4. Vascular lesions: such as varicose veins of the lower limbs, phlebitis, deep vein thrombosis, etc., may appear lower limb swelling, itching, pain and other discomfort. For the right side of the leg discomfort, the doctor needs to combine clinical symptoms, pain location, specific imaging tests to confirm the diagnosis, timely hospitalization, and improve the examination and treatment.