The monocyte ratio of 10.30% cannot be used alone to determine whether the disease is serious or not, but should be combined with other indicators and the patient’s condition. Under normal circumstances, monocytes account for 3%-8% of the total number of white blood cells, and anything above or below this value is abnormal. If only the monocyte ratio is abnormal, it cannot diagnose the disease, and it is necessary to combine with other indicators, such as white blood cell values and lymphocyte values, whether there are clinical symptoms, and combine with the results of the imaging to make a comprehensive assessment. If other indicators are normal and the patient has no obvious discomfort, a monocyte ratio of 10.30% is not serious and does not require treatment, so it can be observed first, or it can be rechecked in a few days. If the monocyte ratio is 10.30% and the white blood cells are high, it may be an acute infection, etc. If the monocyte ratio is 10.30% and the white blood cells are normal or low, it may be acute monocytic leukemia, etc. These cases are more serious and need further examination to clarify the diagnosis and then treatment. Patients with abnormal monocyte ratio are advised to consult their doctors for a systematic evaluation in the context of their condition.