Pharmacological treatment of long-term constipation includes: 1, drugs that promote gastrointestinal motility, such as Mosapride, Sinipride, etc. can promote gastrointestinal motility and bowel excretion. 2, intestinal probiotics can be used, for some patients using intestinal probiotics, can also promote the excretion of stool. 3, when the stool is dry and can not be discharged, glycerin suppositories or corkage can be used to facilitate laxation. 4, daily life can be used osmotic laxatives and Bulking agents, such as oxytetracycline, mannitol, magnesium sulfate, polyethylene glycol 4000, generally with lactulose 15-30ml, 2 times / day, according to the patient’s symptoms can increase the amount. 5, is not recommended to use stimulating laxatives, such as castor oil, rhubarb, senna, etc., because it may cause damage to the colonic mucosa and colonic melanosis.