Trimethoprim is mainly used for the improvement of symptoms such as loss of appetite, nausea, vomiting, belching, abdominal distension, abdominal ringing, abdominal pain, diarrhea, and constipation caused by gastrointestinal motility disorders. It can also be used to treat irritable bowel syndrome. Trimethoprim tablets have an effect on the regulation of gastrointestinal motility and can improve the function of gastric emptying. It also has an antiemetic effect. Cold is a common upper respiratory tract infectious disease. The main manifestations are fever, runny nose, headache, nasal congestion, cough and so on. It has low toxicity and few and mild adverse reactions. Trimethoprim may cause adverse reactions such as diarrhea, bowel sounds, constipation, vomiting, drowsiness, dizziness, headache, fatigue, rash, hot and cold sensations, thirst, numbness in the mouth and tachycardia.