1. Dose individualization. It should be clear that even if the drug is administered according to body weight, the drug concentration in the blood can still vary due to individual differences. Different doses should be selected for different patients in conjunction with clinical practice. The elderly should use drugs with a short half-life. 2. Small and medium doses of NSAID have antipyretic and analgesic effects, while large doses have anti-inflammatory effects. 3.Usually choose one kind of NSAID, after 2-3 weeks of full dose use is not effective, then replace another kind, and gradually reduce the dose after it is effective. 4.It is not recommended to use two NSAIDs at the same time, because the efficacy does not increase, but the side effects increase. 5.After choosing a series of NSAIDs, if there is no outstanding efficacy, cheaper and safer drugs can be used. 6.When there are two to three gastrointestinal risk factors present, ulcer prevention drugs should be added or selective COX-2 inhibitors with high gastrointestinal safety (e.g. Cilazol) should be chosen. 7.When there is one renal risk factor, choose the appropriate NSAID (such as sulforaphane); when there are two or more renal risk factors, avoid using NSAID. 8.When using NSAID, pay attention to the interaction with other drugs, such as beta-blockers can reduce the effectiveness of NSAID; when applying anticoagulants, avoid taking aspirin at the same time; when combined with digitalis, pay attention to prevent digitalis When combined with digitalis, care should be taken to prevent digitalis poisoning.