A small bubble between the black and white eyeballs can be seen in conjunctival edema, vesicular conjunctivitis and conjunctival tissue lymphocysts and other conditions. 1. Globe conjunctival edema: Globe conjunctival edema can occur when excessive rubbing of the eye, manifested as small blisters located in the white eyeballs, not accompanied by other discomfort, can be absorbed, without special treatment. 2. Vesicular conjunctivitis: patients with vesicular conjunctivitis may have blisters at the junction of the black and white eyeballs, which is mostly caused by immune response, and can be treated with hormone eye drops, such as flomilon eye drops, as prescribed by the doctor. 3. Conjunctival tissue lymphocysts: usually no obvious symptoms, partially visible in the white eye in bunches of small blisters, mostly through hot compresses to make it dissipate, can not be dissipated by the need for surgical treatment. A small bubble between the black and white eyeballs may also be caused by other reasons, accompanied by obvious discomfort, it is recommended to consult a doctor for examination and treatment.