PD-1 used in medicine is usually called PD-1 inhibitor, which belongs to a kind of immune anti-tumor targeted drugs. Pabolizumab, Tirilizumab, etc. are PD-1 inhibitors.PD-1 inhibitor side effects include skin side effects, endocrine side effects, immune pneumonitis, hepatitis, myocarditis, and kidney damage. PD-1 inhibitors may have flu-like side effects such as fever, malaise, headache, nausea, cough, or skin and mucous membrane toxicity, which may occur within 3 to 6 weeks of PD-1 use, and can be treated with simple topical therapy or hormonal medications, such as hydrocortisone and dexamethasone. Some patients may also experience immune-related adverse reactions, such as pneumonia, colitis, hepatitis, endocrinopathy, nephritis, immune myocarditis, etc., as well as endocrine abnormalities, such as diabetes mellitus, thyroid function abnormalities, including hyperthyroidism, hypothyroidism, and cortisol lowering and other side effects. Patients are advised to use it under the guidance of a doctor, and if side effects occur after taking it, they should seek medical treatment promptly.