There are many reasons why itching occurs after having used Sindilizumab, it may be a side effect of Sindilizumab or it may be due to various skin diseases. Sindilizumab can inhibit the growth of tumor cells and is mainly used in the treatment of some patients with classical Hodgkin’s lymphoma. Its side effects are more, its common adverse reactions are fever, hypothyroidism, weight gain, pneumonia, cough, pruritus, etc., allergic to the product is prohibited. Pruritus occurred in some patients after using Sindilizumab. In addition to the side effects of Sindilizumab, pruritus may also be caused by various skin conditions such as fungal skin infections, atopic dermatitis, urticaria, neurodermatitis, etc. It is recommended to consult a physician and identify the cause of the disease and treat it accordingly.