The cause of fever with high ultrasensitive c-reactive protein may be an infectious disease, or an inflammatory response due to non-infectious diseases, and general treatment and medication, etc. should be chosen according to the specific cause of the disease. 1. Infectious diseases. Often due to bacterial, viral, mycoplasma and other pathogenic bacteria infection caused by the inflammatory reaction of the disease, there will be hypersensitive C-reactive protein high fever. Need anti-infective treatment, such as bacterial infection, can use cefoperazone and other anti-infective treatment; for example, viral infection, can use ribavirin and other antiviral drugs to fight infection; mycoplasma infection, the use of azithromycin and other macrolides anti-infective treatment. 2. Non-infectious diseases. For example, pyrexia can lead to disorders of the thermoregulatory center, fever, causing an inflammatory response in the body, and high ultrasensitive C-reactive protein. Treatment needs to get out of the high temperature and high humidity environment, transfer to a cool and ventilated environment, and at the same time replenish fluids to improve symptoms. For example, systemic lupus erythematosus, rheumatic fever and other rheumatic immune diseases can also cause hypersensitivity C-reactive protein high fever, need to take methylprednisone, leflunomide and other anti-rheumatic immune drug treatment. In conclusion, there are many possible causes of hypersensitive C-reactive protein fever, which need to be treated under the guidance of professional doctors.