Copper blue protein, also known as copper oxidase, is elevated in some infectious diseases, such as tuberculosis; in malignant neoplastic diseases, especially those of the hematological system; and in patients with hyperthyroidism. Under normal circumstances, it may also be elevated if the patient is taking oral contraceptives or during pregnancy. Patients with nephrotic syndrome, or following hypoproteinemia due to liver disease, may also have high levels of copper blue protein. For the hepatobiliary system, it is most common for patients to develop hepatomegaly, also known as Wilson’s disease. In this type of disease, the patient will have elevated copper blue protein, and should be actively observed to see if the patient has other systemic lesions, extrapyramidal manifestations, early cirrhosis or unexplained ascites, or even hepatic failure. For such cases, if the patient is diagnosed with hepatomegaly, dietary control and drug treatment should be actively carried out at an early stage.