If hand swelling occurs when walking but not at other times, it is most likely due to the accumulation of water in the hand under the effect of gravity, which is a physiological factor and does not require special treatment. If hand swelling occurs repeatedly and tends to get worse gradually, pathological factors should be excluded. The more common pathological causes are kidney disease, liver disease, thyroid disease and heart disease, such as nephritis, nephrotic syndrome, liver cirrhosis, hypothyroidism and right heart failure. In addition to the symptoms of hand swelling, these diseases are accompanied by other symptoms, such as cloudy urine, foam, more pronounced abdominal swelling, black stools, fear of cold, and shortness of breath after activity. Of course, to confirm the diagnosis, appropriate tests such as urine routine, liver and kidney function, thyroid function, and heart ultrasound should be performed.