Probiotics can improve intestinal flora disorders and assist in the treatment of Helicobacter pylori infection, but they are not effective when used alone. Helicobacter pylori is a bacterium that lives in the mucous membrane of the human stomach, and infection with this bacterium can cause a variety of digestive diseases. Probiotics are active microorganisms that are beneficial to the human intestinal tract, and this drug can regulate the balance of intestinal flora and inhibit the growth of H. pylori. Clinically, H. pylori is usually eliminated using quadruple therapy, which consists of a proton pump inhibitor, bismuth and two antibiotics, such as omeprazole, bismuth pectin, amoxicillin and clarithromycin. It can be effective in eradicating H. pylori, but a single drug is not effective in treating H. pylori. Combined probiotic treatment has been found to improve the eradication of H. pylori in current studies, but it has not been included in the treatment yet. Patients infected with H. pylori should go to the hospital in time for examination, and if the examination has shown inflammation or other lesions should receive timely treatment.