A herniated L5-S1 disc is also known as a herniated disc in the last section of the body. The last disc of the spine, also known as the L5/S1 disc, is the one that is under the most pressure of all the discs and is one of the most common herniated discs in clinical practice. A herniated disc can cause pain and numbness in the lower back, buttocks, and legs when it presses on the spinal cord and nerve roots. Once the symptoms of herniated disc appear, conservative treatment can be carried out first, such as paying attention to rest, avoiding heavy physical labor, lumbar hot compresses, acupuncture, grilled electricity and other physical therapy treatments. Oral anti-inflammatory and analgesic drugs such as nimesulide and diclofenac sodium as well as neurotrophic drugs such as methylcobalamin and adenosylcobalamin can also be taken for treatment. For severe lumbar disc herniation, surgical treatment is also available, such as spinal canal decompression and bone graft fusion and internal fixation surgery. Once the symptoms of L5/S1 disc herniation occur, it is recommended that the patient go to the hospital for medical examination and receive regular treatment after completing the examination. The above medications should be used under the guidance of a doctor, and avoid self-medication.