The appearance of carbon monoxide poisoning headache can be relieved by means of hyperbaric oxygen and drugs, as follows: first, hyperbaric oxygen therapy: hyperbaric oxygen has special effects on carbon monoxide poisoning, and it is recommended to do hyperbaric oxygen continuously in the early stage, twice a day, even if the patient’s symptoms all disappear to do one more course of treatment, which can avoid delayed encephalopathy; second, drug therapy: B vitamins and some hormones should be used, and through these Second, medication: B vitamins and some hormones should be used to reduce the edema and inflammatory reaction of brain cells to avoid delayed encephalopathy. Patients with headache can be temporarily treated with dehydrating and cranial pressure lowering drugs, such as mannitol. In addition, neurotrophic drugs such as gangliosides can also be used, and these can be helpful in relieving the headache as well as the sequelae.