Thickening of liver echogenicity, intrahepatic hypoechoic nodules, and splenomegaly are the first considerations for portal hypertension due to cirrhosis, which may be combined with splenomegaly. In cirrhosis, the obstruction of blood flow leads to elevated portal vein pressure manifesting as ascites and splenomegaly. Due to the elevated portal vein pressure, the splenic vein reflux is obstructed and the spleen is silted up, so the spleen becomes enlarged. In addition to splenomegaly there can also be hypersplenism, which is characterized by a decrease in peripheral blood, most commonly leukopenia and thrombocytopenia. For patients with cirrhosis, in addition to evaluating the performance of liver ultrasound, the severity of cirrhosis can also be determined based on the 5 items of hepatitis B, the number of hepatitis B virus replication, the 4 items of liver fibers, liver hardness test, and gastroscopy evaluation of fundal esophageal varices, so as to determine the severity of cirrhosis and to adopt a reasonable therapeutic plan. For patients presenting with thickened liver echogenicity, intrahepatic hypoechoic nodules and splenomegaly, they should consult the hepatobiliary surgery department of a regular hospital.