The causes of redness on both sides of the cheeks include physiological factors and pathological factors such as rosacea and systemic lupus erythematosus, etc. You can choose different medications to improve the redness on both sides of the cheeks according to different causes. 1. Physiological factors: If blood vessels dilate due to a hot environment, this is a physiological phenomenon and does not require special treatment. 2. Rosacea: Erythematous capillary dilatation rosacea is characterized by symmetrical occurrence of erythema in the middle of the face, especially in the nose, cheeks, forehead, jaw and other parts of the face, and persistent redness can occur in response to different stimuli, such as changes in ambient temperature, etc., which can be treated with topical azelaic acid cream. 3. Systemic lupus erythematosus: due to the attack of autoimmune system, fever, arthralgia and pteroidal erythema on the face are the most common early symptoms of the disease, glucocorticoid such as prednisone or immunosuppressant such as hydroxychloroquine sulfate can be given to inhibit the immune therapy. All of the above drugs should be used in accordance with the doctor’s instructions, there are more reasons for the appearance of redness on both sides of the cheeks, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease and then treatment.