The coexistence of ulcers in the anterior pyloric region and ulcers in the bulb of the 12 finger intestine can be treated by general treatment, medications such as omeprazole and thioglycollate, and surgery if necessary. 1. General treatment: keep a good mood and life habits, quit smoking and avoid alcohol, avoid intake of stimulating food, avoid intake of coffee and strong tea. 2. Drug treatment: mainly include acid-suppressing treatment such as proton pump inhibitor omeprazole, etc., gastric mucosal protective agent such as aluminum thioglycollate, etc.. 3. Surgery: If the internal medicine treatment is ineffective, or if there is a lot of bleeding or repeated bleeding, or if there is a refractory ulcer, surgery can be carried out. If there are ulcers in the anterior pyloric region and ulcers in the bulb of the 12 fingers intestine at the same time, you should consult a doctor in time, and the relevant drugs should be used under the guidance of a doctor.