Severe stenosis of the left anterior descending branch is serious and timely consultation and standardized treatment are recommended. The left anterior descending branch is an important branch of the left coronary artery, which mainly supplies the anterior wall of the left ventricle and the interventricular septum. In case of severe stenosis, if the plaque is dislodged and leads to obstruction, triggering an acute infarction, it can be life-threatening, so severe stenosis of the left anterior descending branch is more serious and requires timely consultation and treatment. Generally, when the stenosis is greater than 75%, it is called severe stenosis. Severe stenosis of the left anterior descending branch can be clarified by coronary CT and coronary angiography, but coronary angiography is the gold standard for diagnosing the stenosis. If the stenosis is clearly identified, a stent should be placed in time. After the operation, anticoagulants and plaque stabilizers, such as aspirin, clopidogrel, atorvastatin, etc., should be taken according to the doctor’s instructions, and the patient should undergo regular checkups. If physical examination reveals cardiac stenosis or symptoms such as discomfort in the precordial region, consult a doctor promptly to avoid delays.