ebVirus infections that cause heterotypic lymphocytes require antiviral therapy such as ganciclovir as well as interferon therapy. Elevated heterophilic lymphocytes require clarification of the cause of the disease before treatment. If it is induced by ebV infection, it is usually accompanied by fever symptoms. Acute ebV infection can be treated with ganciclovir and interferon. The common adverse effects of ganciclovir include anemia, fever, fatigue, infection, headache and hair loss, etc. Ganciclovir is contraindicated in pregnant women, breastfeeding women and those who are allergic to ganciclovir; the common adverse effects of interferon include fever, fatigue, myalgia, and headache, etc., and it should be used with caution in case of allergy. In addition, the application of the above drugs, there is a certain degree of risk, patients need to get the guidance of a specialist.