Corner of the mouth pimples may be folliculitis, acne, allergies, etc. There is no quick way to eliminate them, and it is important to choose the appropriate treatment according to the nature of the pimples, such as topical medication or systemic medication. 1. Folliculitis: Folliculitis is an inflammation caused by bacteria and other pathogens infecting the hair follicles. Local hygiene should be paid attention to, and if it cannot heal on its own or if the folliculitis is large, it can be disinfected with chlorhexidine gluconate solution, iodophor solution, and antibiotic ointment can be applied, such as erythromycin ointment, mupirocin ointment and so on. 2. Acne: sebum secretion, Propionibacterium acnes overpopulation caused by skin diseases, mainly topical drugs, such as isotretinoin, tazarotene, if combined with bacterial infection, you can choose antibiotic drugs, such as erythromycin ointment, fusidic acid cream. 3. Allergy: If you are allergic to some of the food that causes allergies can also cause acne in the corners of the mouth, this situation generally stop contact with allergens after the symptoms will gradually disappear, for the symptoms are more serious, long duration of the patient can take oral loratadine, cetirizine. There may be other causes of acne at the corners of the mouth, it is recommended to go to the hospital for further examination, to clarify the cause of the disease, targeted treatment, and if you need to use medication to strictly comply with the doctor’s instructions.