Fenofibrate and atorvastatin are not usually recommended to be taken together, but for patients with both high cholesterol and high triglyceridemia, the combination of the two medications can reduce the amount of a single medication and enhance the lipid-regulating effect. Fenofibrate can lower cholesterol and triglycerides, and can treat adults with hypertriglyceridemia that is not well controlled by diet. Atorvastatin belongs to the statin class of drugs, is commonly used in the clinic of lipid-lowering drugs, can reduce the level of low-density lipoprotein cholesterol, and can stabilize plaque, coronary heart disease, cerebral infarction and other cardiovascular and cerebral vascular diseases have preventive and therapeutic effects. Both fenofibrate and atorvastatin may have an effect on liver function and there is a risk of rhabdomyolysis, so it is generally not recommended to take them at the same time. However, if the patient is hypercholesterolemia and hypertriglyceridemia coexist, the two drugs can be taken simultaneously, which helps to reduce the dosage of a single drug and enhance the efficacy of lipid regulation. The therapeutic effect of taking both drugs at the same time can be somewhat more pronounced than doubling the dose of atorvastatin. When taking the two drugs together, it is recommended to start with a small dose, and during the course of taking the drug, liver function and creatine kinase levels should be checked regularly, and the drug should be discontinued in time if muscle pain or muscle weakness occurs. Specific medication and whether it can be taken in combination, need to follow the doctor’s instructions.